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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Arp3 Rabbit Monoclonal Antibody
KD-Validated Anti-Arp3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P61158 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB615 |
| Calculated MW | Predicted, 47 kDa; Observed, 47 kDa |
| Gene Name | ACTR3 |
| Aliases | ACTR3; Actin Related Protein 3; ARP3; ARP3 Actin Related Protein 3 Homolog; Actin-Related Protein 3; Actin-Like Protein 3; ARP3 (Actin-Related Protein 3, Yeast) Homolog; ARP3 Actin-Related Protein 3 Homolog (Yeast) |
| Immunogen | A synthesized peptide derived from human ACTR3 |
| Gene ID | 10096 |
|---|---|
| Other Names | Actin-related protein 3, Actin-like protein 3, ACTR3, ARP3 |
| Name | ACTR3 |
|---|---|
| Synonyms | ARP3 |
| Function | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre- apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554) |
Research Areas
Citations (0)
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2347
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